Asterisks indicate significant differences between groups (* p < 0.05 ** p < 0.01) from two-way ANOVA with repeated measures. (G,H) Graphs (mean ± SEM) show DPOAE responses recorded in NE and NN animals at different ages (3 and 6 M). Asterisks indicate significant differences between groups (* p < 0.05 ** p < 0.01) from Student’s t-test. (E,F) Amplitude-intensity curves (mean ± SEM) showing a decreased amplitude of wave I and wave II in NE animals of 6 M at 16 kHz compared with NN mice. Asterisks indicate significant differences between groups (* p < 0.05 ** p < 0.01) from three way ANOVA with repeated measures. Threshold increase was evident also at 6 M (C), whereas, at 9 M, the threshold also worsened in not-exposed group and no difference was observed between the groups (D). At 3 M, noise causes a marked increase of auditory threshold, spanning at all frequencies (B). (B–D) Graphs show ABR threshold values (means ± SEM) in animals exposed to noise in young age and evaluated at 3, 6, and 9 M (corresponding to 1, 4, and 7 months after noise exposure). A progressive worsening of auditory threshold was observed in NN mice during physiological aging. (A) Graph shows ABR threshold values (means ± SEM) in mice of 3, 6, and 9 months of age (M). (A–D) ABR recordings in no noise-exposed (NN) and/or noise-exposed (NE) C57BL/6 mice at different months of age. Noise-induced hearing loss accelerates auditory dysfunctions in 6 months of age mice. Unveiling the molecular mechanisms underlying the link between hearing loss and aging processes could be valuable to identify effective therapeutic strategies to limit the effect of environmental risk factors on age-related diseases.Īcoustic trauma age-related hearing loss aging hearing loss oxidative stress vascular dysfunction.Ĭopyright © 2022 Fetoni, Pisani, Rolesi, Paciello, Viziano, Moleti, Sisto, Troiani, Paludetti and Grassi. Moreover, we studied common pathological markers shared between hearing loss and ARHL, demonstrating that noise exposure can worsen/accelerate redox status imbalance and vascular dysfunction in the cochlea. We found that hearing loss can exacerbate ARHL, damaging sensory-neural cochlear epithelium and causing synaptopathy. In this study, we used an established animal model of ARHL (C57BL/6 mice) to evaluate if early noise-induced hearing loss (NIHL) could affect the onset or progression of age-related cochlear dysfunction. Although the association between hearing impairment in midlife and ARHL has been widely documented by epidemiological and experimental studies, the molecular mechanisms underlying this association are not fully understood. Several studies identified hearing loss as a risk factor for aging-related processes, including neurodegenerative diseases, as dementia and age-related hearing loss (ARHL).
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